Endocrine Abstracts

Background: Adrenal vein sampling (AVS) is the gold-standard for localizing the site of autonomous aldosterone production in patients with primary aldosteronism (PA). The procedure is technically challenging with a reported success rate of 50-95%.Aim: To audit the success rate of AVS at a regional referral unit.Standards: No set standard exists. 80% success rate was taken as the minimum acceptable standard for a tertiary referral c...

Context: Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules’ volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified.Objective: To analyze the correlation of RFA power, duration and energy with VRR.Design: Prospective study from June 2018 to December 2019.Setting: Two primary-care centers using the same RF...

Background and objectives: Goitre is still one of endemic health problems in Gorgan city after one decade of universal salt iodization in Iran. Hypothyroism have different complications in children that between them, developmental disorders of CNS are so important. This study proposed to determine that prevalence of thyroid function and volume disorders and its correlation with IQ in the mental retard (MR) children.Material and methods: This cross-sectio...

Objective: The aim of this exploratory study was to assess the effect of growth hormone on semen parameters in men with primary infertility and normogonadotropic idiopathic oligoasthenospermia.Method: This study was performed as a prospective, open- label, non-randomized observational study in a private practice in fourteen men, aged 26 to 35, with normogonadotropic idiopathic oligoasthenospermia. Growth hormone 1.5 IU/day was administered for 6 months a...

Background: Disturbance of thyroid hormones metabolism and morphology is common in ESRD (end stage renal disease) but there are discrepancies between data after transplantation. The aim of this study was assessment of the thyroid function and morphology after renal transplantation surgery.Material and method: All recipient patients, without previous history of thyroid disorders, were enrolled. Serum level of creatinine, total T3 and T4 (TT3, TT4), resin ...

Objectives: Image-guided thermal-ablation (LTA; RFA) are well established therapy options in selected BTN. PMWT is a mini-invasive technique recently applied in thyroid disease; aim of this work is investigate its effectiveness as treatment in BTN.Methods: From May 2021, 45 patients (30 F, 15 M, Aged 37-90, Mean 55,8) with BTN symptomatic/in growing, refusing/non eligible to surgery were enrolled. Inclusion criteria: nodule diameter ≥ 2 cm, mainly ...

Introduction: Long-standing type 2 diabetes (DM) is associated with brain atrophy. In this prospective study we examined the impact of glycaemic status on total brain volume in an elderly cohort.Methods/Design: Two-year follow-up study of a population-derived cohort of non-demented community-dwelling adults aged 70–90 years (Sydney Memory and Aging Study). Prospective MRI and metabolic data were available in 312 of the 542 participants who had a MRI...

Background: In experimental studies, a high fluid intake and a corresponding high urine volume have been shown to increase renal excretion rates of urinary free cortisol (UFF) and cortisone (UFE) in adults. We aimed to examine whether 24-h urinary steroid excretion rates are also affected by urine volume in children.Methods: In 24-h urine samples of 100 prepubertal and 100 pubertal healthy children UFF, UFE, tetrahydrocortisol, 5α-tetrahydrocortisol...

Background: Hypothalamic damage caused by craniopharyngioma (CP) is related to memory deficits, disturbed attention, and impaired processing speed. This is the first study that aims to establish a structure to function relationship by assessing cognitive function in adult patients with childhood-onset (CO) CP along with volumetric analysis of the hypothalamus.Method: Forty-one (24 women) surgically treated CO-CP patients (median age at diagnosis; 11 year...

Introduction: Surgery remains the first-line treatment of clinically non-functioning pituitary adenomas (NFPA). However, the presence of somatostatin receptors (SSTR) in these tumours forms the basis of clinical use of somatostatin analogues (SSA). Visualisation of SSTR in scintigraphy is compulsory to introduce SSA therapy in NFPA.Aim: To assess the effectiveness of long-term somatostatin analogues treatment on tumour volume and visual field in patients...